Synthesis of Thiadiazole Based Carbamates as Potent Endocannabinoid-hydrolyzing Enzyme Inhibitors
نویسنده
چکیده
.................................................................................................2 Acknowledgement .....................................................................................4 Abbreviations ........................................................................................................................5 1. Literature Review: Recent development of FAAH/MGL inhibitors...............................9 1.
منابع مشابه
The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors.
A series of para-substituted phenolic N-alkyl carbamates were evaluated for their FAAH and MGL inhibitory activities. The compounds were generally selective for FAAH, with IC(50) values in the nM range, whereas inhibition of MGL required concentrations three orders of magnitude higher. The most potent compounds, dodecylcarbamic acid 4-(4,5-dihydrothiazol-2-yl)phenyl (12) and 4-(1,2,3-thiadiazol...
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